Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review

Involvement of the NMDA System in Learning and Memory

Amir H. Rezvani  1
Edward D Levin  1 , Jerry J Buccafusco  2
, editors.
In: Animal Models of Cognitive Impairment. Boca Raton (FL): CRC Press/Taylor & Francis; 2006. Chapter 4.
Frontiers in Neuroscience.
Affiliations
Free Books & Documents
Review

Involvement of the NMDA System in Learning and Memory

Amir H. Rezvani.
Free Books & Documents

Excerpt

Since its discovery in the early 1950s, the N-methyl-D-aspartate (NMDA) receptor system in the brain has been implicated in many fundamental functions, including neuronal plasticity, neurotoxicity, learning, and memory (Riedel et al., 2003). The aim of this chapter is to summarize the current findings on the role of glutamate-receptor systems in learning and memory in different animal models and humans. The structure, localization, and pharmacology of these receptors will not be discussed in this chapter. For those who are interested in these particular topics, we refer them to an excellent recent review (Riedel et al., 2003).

PubMed Disclaimer

References

    1. Abdul-Monim Z, Reynolds GP, Neill JC. The atypical antipsychotic ziprasi-done, but not haloperidol, improves phencyclidine-induced cognitive deficits in a reversal learning task in the rat. J Psychopharmacol. 2003;17:57–65. - PubMed
    1. Aebischer B, Frey P, Haerter HP, Herrling PL, Mueller W, Olverman HJ, et al. Synthesis and NMDA antagonistic properties of the enantiomers of 4-(3-phosphono-propyl)piperazine-2-carboxylic acid (CPP) and of the unsaturated analogue (E)-4-(3-phosphonoprop-2-enyl)piperazine-2-carboxylic acid (CPP-ene) Helvetica Chimica Acta. 1989;72:1043–1047.
    1. Benvenga MJ, Spaulding TC. Amnesic effect of the novel anticonvulsant MK-801. Pharmacol, Biochem Behav. 1988;30:205–207. - PubMed
    1. Butelman ER. The effect of NMDA antagonists in the radial arm maze task with an interposed delay. Pharmacol, Biochem Behav. 1990;35:533–536. - PubMed
    1. Carey RJ, Dai H, Gui J. Effects of dizocilpine (MK-801) on motor activity and memory. Psychopharmacology. 1998;137:241–246. - PubMed

LinkOut - more resources