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. 2011 Jul;72(1):162-3.
doi: 10.1111/j.1365-2125.2010.03892.x.

5-Fluorouracil-based chemotherapy for colorectal cancer and MTHFR/MTRR genotypes

Barbara Pardini, Rajiv Kumar, Alessio Naccarati, Jan Novotny, Rashmi B Prasad, Asta Forsti, Kari Hemminki, Pavel Vodicka, Justo Lorenzo Bermejo

5-Fluorouracil-based chemotherapy for colorectal cancer and MTHFR/MTRR genotypes

Barbara Pardini et al. Br J Clin Pharmacol. 2011 Jul.
No abstract available

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References

    1. Longley DB, Harkin DP, Johnston PG. 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer. 2003;3:330–8. - PubMed
    1. Afzal S, Jensen SA, Vainer B, Vogel U, Matsen JP, Sorensen JB, Andersen PK, Poulsen HE. MTHFR polymorphisms and 5-FU-based adjuvant chemotherapy in colorectal cancer. Ann Oncol. 2009;20:1660–6. - PubMed
    1. Canman CE, Lawrence TS, Shewach DS, Tang HY, Maybaum J. Resistance to fluorodeoxyuridine-induced DNA damage and cytotoxicity correlates with an elevation of deoxyuridine triphosphatase activity and failure to accumulate deoxyuridine triphosphate. Cancer Res. 1993;53:5219–24. - PubMed
    1. Canman CE, Tang HY, Normolle DP, Lawrence TS, Maybaum J. Variations in patterns of DNA damage induced in human colorectal tumor cells by 5-fluorodeoxyuridine: implications for mechanisms of resistance and cytotoxicity. Proc Natl Acad Sci USA. 1992;89:10474–8. - PMC - PubMed
    1. de Gramont A, Figer A, Seymour M, Homerin M, Hmissi A, Cassidy J, Boni C, Cortes-Funes H, Cervantes A, Freyer G, Papamichael D, Le Bail N, Louvet C, Hendler D, de Braud F, Wilson C, Morvan F, Bonetti A. Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol. 2000;18:2938–47. - PubMed

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