Targeting IGF-1R: throwing out the baby with the bathwater?
- PMID: 21206496
- PMCID: PMC3039814
- DOI: 10.1038/sj.bjc.6606023
Targeting IGF-1R: throwing out the baby with the bathwater?
Conflict of interest statement
Johann de Bono has served as a paid consultant for Pfizer, Genentech, Novartis, Astellas, Boehringer Ingelheim, Merck, and AstraZeneca.
Comment on
-
Pre-treatment levels of circulating free IGF-1 identify NSCLC patients who derive clinical benefit from figitumumab.Br J Cancer. 2011 Jan 4;104(1):68-74. doi: 10.1038/sj.bjc.6605972. Epub 2010 Nov 23. Br J Cancer. 2011. Retraction in: Br J Cancer. 2012 Dec 4;107(12):2024. doi: 10.1038/bjc.2012.497. PMID: 21102589 Free PMC article. Retracted.
References
-
- Frystyk J (2007) Utility of free IGF-I measurements. Pituitary 10(2): 181–187 - PubMed
-
- Gualberto A, Dolled-Filhart M, Gustavson M, Christiansen J, Wang YF, Hixon ML, Reynolds J, McDonald S, Ang A, Rimm DL, Langer CJ, Blakely J, Garland L, Paz-Ares LG, Karp DD, Lee AV (2010) Molecular analysis of non-small cell lung cancer identifies subsets with different sensitivity to insulin-like growth factor I receptor inhibition. Clin Cancer Res 16(18): 4654–4665 - PMC - PubMed
-
- Han JY, Choi BG, Choi JY, Lee SY, Ju SY (2006) The prognostic significance of pretreatment plasma levels of insulin-like growth factor (IGF)-1, IGF-2, and IGF binding protein-3 in patients with advanced non-small cell lung cancer. Lung Cancer 54(2): 227–234 - PubMed
-
- Jassem J, Langer CJ, Karp DD, Mok T, Benner RJ, Green SJ, Park K, Novello S, Strausz J, Gualberto A (2010) Randomized, open label, phase III trial of figitumumab in combination with paclitaxel and carboplatin versus paclitaxel and carboplatin in patients with non-small cell lung cancer (NSCLC). J Clin Oncol (Meet Abstr) 28(Suppl 15): 7500
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
