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. 2010 Jul 12:1:11.
doi: 10.3389/fneur.2010.00011. eCollection 2010.

Perspectives on the treatment of the longitudinal spinal cord injury

Thomas Carlstedt  1
Affiliations

Perspectives on the treatment of the longitudinal spinal cord injury

Thomas Carlstedt. Front Neurol. .

Abstract

The current technique for surgical treatment of the longitudinal spinal cord injury has proven to be successful for restoration of some motor function and alleviation of pain. This has been the first step in finding a cure for spinal cord injuries, but so far there are many obstacles still to be overcome. In this particular injury return of function from spinal cord surgery is only partial. Some of the main remaining problems are related to injury-induced neuronal death, direction and specificity of regeneration and muscle, and receptor disintegration from long time denervation. Currently this is a surgical procedure without any adjuvant treatments. In order to gain further functional improvement combinational therapies developed in basic science experiments are essential.

Keywords: functional recovery; nerve plexus; root avulsion; spinal cord injury; spinal cord surgery.

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References

    1. Bergerot A., Shortland P. J., Anand P., Hunt S., Carlstedt T. (2004). Co-treatment with riluzole and GDNF is necessary for functional recovery after ventral root avulsion injury. Exp. Neurol. 187, 359–36610.1016/j.expneurol.2004.02.003 - DOI - PubMed
    1. Berman J., Birch R., Anand P. (1998). Pain following human brachial plexus injury with spinal cord root avulsion and the effect of surgery. Pain 75, 199–20710.1016/S0304-3959(97)00220-0 - DOI - PubMed
    1. Bigbee A. J., Hoang T. X., Havton L. A. (2008). Reimplantation of avulsed lumbosacral ventral roots in the rat ameliorates injury-induced degeneration of primary afferent axon collaterals in the spinal dorsal columns. Neuroscience 152, 338–34510.1016/j.neuroscience.2007.11.043 - DOI - PMC - PubMed
    1. Carlstedt T. (1985). Regenerating axons form nerve terminals at astrocytes. Brain Res. 347, 188–19110.1016/0006-8993(85)90911-4 - DOI - PubMed
    1. Carlstedt T. (1985b). Dorsal root innervation of spinal cord neurons after dorsal root implantation into the spinal cord of adult rats. Neurosci. Lett. 55, 343–34810.1016/0304-3940(85)90459-8 - DOI - PubMed

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