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. 2011 Jul;137(7):1071-8.
doi: 10.1007/s00432-010-0971-z. Epub 2011 Jan 5.

Intra-hepatic cholangiocarcinoma--frequency and demographic patterns: thirty-year data from the M.D. Anderson Cancer Center

Ashwani K Singal  1 , Jean-Nicolas Vauthey, James J Grady, John R Stroehlein
Affiliations

Intra-hepatic cholangiocarcinoma--frequency and demographic patterns: thirty-year data from the M.D. Anderson Cancer Center

Ashwani K Singal et al. J Cancer Res Clin Oncol. 2011 Jul.

Abstract

Purpose: Recent reports have shown an increase in frequency of intra-hepatic cholangiocarcinoma (IHC) with a stable or decreased frequency of extra-hepatic cholangiocarcinoma (EHC). However, data on the demographic patterns associated with this change are limited. We analyzed cases of cholangiocarcinoma (CC) with aim to study frequency and demographic patterns over time of IHC and EHC.

Methods: Data were collected from MD Anderson Cancer Center Tumor Registry on CC (1978-2007) and stratified on age (<50, 50-59, 60-69, and ≥70 years), gender, ethnicity (Caucasian, African-American, Hispanic, and Other), time (1978-1987, 1988-1997, 1998-2007), and diagnosis (IHC and EHC). Chi-square tests and logistic regression were used for statistics.

Results: Of 1,061 CC (445 IHC), proportion of IHC increased from 30% in 1978-1998 to 48% during 1998-2007 (P < 0.0001). Compared to EHC, IHC occurred more frequently in relatively young (age < 60 years) (21 and 27% vs. 15 and 23% in 0-49 years and 50-59 years, respectively; P = 0.003) and females (48 vs. 42%, P = 0.03). Ethnic distribution was similar. There was significant (P = 0.019) interaction between age and gender using logistic regression analysis.

Conclusions: Increase in frequency of IHC occurred over time and is more frequently observed among females <60 years. These data may have implications in understanding pathogenesis of IHC.

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Conflict of interest statement

None of the authors have any financial or any other disclosures. No financial support was received for this study.

Figures

Fig. 1
Fig. 1
Annual frequency distribution (1978–2007) of cases with intra-hepatic cholangiocarcinoma (IHC) and extra-hepatic cholangiocarcinoma (EHC)
Fig. 2
Fig. 2
Percent distribution of intra-hepatic cholangiocarcinoma (IHC) and extra-hepatic cholangiocarcinoma (EHC) by age group in years (<50, 50–59, 60–69, and ≥70) during 3 deacdes (1978–1987, 1988–1997, and 1998–2007). Results show that when compared to EHC, IHC is common among patients ≤60 years of age. The overall association of age- and site-specific diagnosis (IHC or EHC) controlling for time interval was significant (P = 0.0001)
Fig. 3
Fig. 3
Percent distribution of intra-hepatic cholangiocarcinoma (IHC) and extra-hepatic cholangiocarcinoma (EHC) by gender during 3 deacdes (1978–1987, 1988–1997, and 1998–2007). Results show that the distribution was not different separately in each decade and did not change over time
Fig. 4
Fig. 4
Percent distribution of intra-hepatic cholangiocarcinoma (IHC) and extra-hepatic cholangiocarcinoma (EHC) by gender and age group in years (<50, 50–59, 60–69, and ≥70). Results show that when compared to EHC, IHC was more common among ≤60 years of age
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