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. 2011 Jan;41(1):165-74.
doi: 10.1007/s10519-010-9437-y. Epub 2011 Jan 5.

A family based association study of DRD4, DAT1, and 5HTT and continuous traits of attention-deficit hyperactivity disorder

L Cinnamon Bidwell  1 , Erik G Willcutt, Matthew B McQueen, John C DeFries, Richard K Olson, Shelley D Smith, Bruce F Pennington
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A family based association study of DRD4, DAT1, and 5HTT and continuous traits of attention-deficit hyperactivity disorder

L Cinnamon Bidwell et al. Behav Genet. 2011 Jan.

Abstract

Despite its high heritability, genetic association studies of attention deficit-hyperactivity disorder (ADHD) have often resulted in somewhat small, inconsistent effects. Refining the ADHD phenotype beyond a dichotomous diagnosis and testing associations with continuous information from the underlying symptom dimensions may result in more consistent genetic findings. This study further examined the association between ADHD and the DRD4, DAT1, and 5HTT genes by testing their association with multivariate phenotypes derived from continuous measures of ADHD symptom severity. DNA was collected in 202 families consisting of at least one ADHD proband and at least one parent or sibling. VNTR polymorphisms of the DRD4 and DAT1 genes were significantly associated with the continuous ADHD phenotype. The association with DRD4 was driven by both inattentive and hyperactive symptoms, while the association with DAT1 was driven primarily by inattentive symptoms. These results use novel methods to build upon important connections between dopamine genes and their final behavioral manifestation as symptoms of ADHD.

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References

    1. Abecasis G, Cherny S, Cookson WO, Cardon LR. Merlin-rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet. 2002;30:97–101. - PubMed
    1. Anderson BM, Schnetz-Boutaud N, Bartlett J, Wright HH, Abramson RK, Cuccaro ML, Gilbert JR, Pericak-Vance MA, Haines JL. Examination of association to autism of common genetic variationin genes related to dopamine. Autism Res. 2008;1(6):364–369. - PMC - PubMed
    1. Asghari V, Schoots O, van Kats S, Ohara K, Jovanovic V, Guan HC, Bunzow JR, Petronis A, Van Tol HH. Dopamine D4 receptor repeat: analysis of different native and mutant forms of the human and rat genes. Mol Pharmacol. 1994;46(2):364–373. - PubMed
    1. Barkley RA, Murphy K. Attention-deficit hyperactivity disorder: A clinical workbook. 2nd. ed. New York: Guilford Press; 1998.
    1. Bidwell LC, Willcutt EG, DeFriest JC, Pennington BF. Testing for neuropsychological endophenotypes in siblings discordant for ADHD. Biological Psychiatry. 2007;62:991–998. - PMC - PubMed

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