doi: 10.1007/978-1-61737-985-7_16.
Electrospray ionization tandem mass spectrometry (ESI-MS/MS)-based shotgun lipidomics
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- PMID: 21207296
- DOI: 10.1007/978-1-61737-985-7_16
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Electrospray ionization tandem mass spectrometry (ESI-MS/MS)-based shotgun lipidomics
Methods Mol Biol.
2011.
Abstract
In the past decade, many new strategies for mass spectrometry (MS)-based analyses of lipids have been developed. Lipidomics is one of the most promising research fields to emerge as a result of these advances in MS. Currently, mass spectrometric analysis of lipids involves two complementary approaches: direct infusion (shotgun lipidomics) and liquid chromatography coupled to MS. In this chapter, I will demonstrate the approach of shotgun lipidomics using electrospray ionization tandem MS for the analysis of lipid molecular species directly from crude biological extracts of tissue or fluids.
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