Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Mar;10(2):114-20.
doi: 10.1016/j.jcf.2010.12.002. Epub 2011 Jan 3.

Decreased mucosal oxygen tension in the maxillary sinuses in patients with cystic fibrosis

Kasper Aanaes  1 , Lars Fledelius Rickelt, Helle Krogh Johansen, Christian von Buchwald, Tacjana Pressler, Niels Høiby, Peter Østrup Jensen
Affiliations
Free article

Decreased mucosal oxygen tension in the maxillary sinuses in patients with cystic fibrosis

Kasper Aanaes et al. J Cyst Fibros. 2011 Mar.
Free article

Abstract

Background: Pseudomonas aeruginosa in the sinuses plays a role in the lungs in cystic fibrosis (CF) patients, but little is known about the sinus environment where the bacteria adapt. Anoxic areas are found in the lower respiratory airways but it is unknown if the same conditions exist in the sinuses.

Methods: The oxygen tension (pO(2)) was measured, using a novel in vivo method, in the maxillary sinus in a group of 20 CF patients.

Results: The CF patients had a significant lower pO(2) on the mucosa but not in the sinus lumen as compared with a control group of non-CF patients. Anoxic conditions were found in 7/39 (18%) of the sinuses from where we cultured P. aeruginosa, Stenotrophomonas maltophilia and/or coagulase negative staphylococci.

Conclusion: These findings support our hypothesis that P. aeruginosa can adapt or acclimate to the environment in the lungs, during growth in anoxic parts of the paranasal sinuses.

PubMed Disclaimer

Publication types