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Comparative Study
. 2011 Apr;23(4):308-15.
doi: 10.1111/j.1365-2982.2010.01660.x. Epub 2011 Jan 6.

Performance characteristics of the measurement of gastric volume using single photon emission computed tomography

M Breen  1 , M Camilleri, D Burton, A R Zinsmeister
Affiliations
Comparative Study

Performance characteristics of the measurement of gastric volume using single photon emission computed tomography

M Breen et al. Neurogastroenterol Motil. 2011 Apr.

Abstract

Background: A non-invasive single photon emission computed tomography (SPECT) method was developed and validated to measure gastric volumes (GV). The natural variation in gastric volume responses and performance characteristics of SPECT imaging are unclear.

Methods: The primary aim of this study was to assess the performance characteristics of SPECT imaging by estimating the inter-individual coefficients of variation (COV) in fasting and postprandial GV in 433 participants in prior research studies over the last decade, and the intra-individual COV in all volunteers who had undergone at least two studies. The secondary aim was to assess the relationship of gender, BMI and age on GV.

Key results: The COV(INTER) for all subjects in the study (n = 433) was 32.6% fasting, 16.0% fed, and 19.0%Δ fed - fasting. The COV(INTRA) for 47 subjects with repeat estimates of gastric volume was 37.0% fasting, 17.6% fed, and 22.0%Δ fed - fasting. COV(INTRA) was stable over time interval from 2 to 60 months. There were no significant differences by gender or subgroups. Mean fed and gastric accommodation volumes were associated with age and BMI but the magnitude of variation attributable was <5%.

Conclusions & inferences: COV(INTRA) and COV(INTER) of GV by SPECT are very similar, and there is a small effect of age and BMI. These data are important for planning future studies of GV and further validate SPECT for studies of gastric motility disorders and obesity.

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Conflict of interest statement

Disclosures: The authors report no conflicts of interest relevant to this article.

Figures

Figure 1
Figure 1. Intra-individual reliability of gastric volume measurements by SPECT
A. All healthy participants, n=47 B. Female participants, n=29 C. Male participants, n=18
Figure 1
Figure 1. Intra-individual reliability of gastric volume measurements by SPECT
A. All healthy participants, n=47 B. Female participants, n=29 C. Male participants, n=18
Figure 1
Figure 1. Intra-individual reliability of gastric volume measurements by SPECT
A. All healthy participants, n=47 B. Female participants, n=29 C. Male participants, n=18
Figure 2
Figure 2
Differences in gastric volume over different time intervals in the 47 healthy volunteers
Figure 3
Figure 3
Relationship of postprandial gastric volumes and age (A) and body mass index (B)
Figure 3
Figure 3
Relationship of postprandial gastric volumes and age (A) and body mass index (B)
See this image and copyright information in PMC

References

    1. Kuiken SD, Samsom M, Camilleri M, Mullan BP, Burton DD, Kost LJ, Hardyman TJ, O’Connor MK. Development of a test to measure gastric accommodation in humans. Am J Physiol. 1999;277:G1217–G1221. - PubMed
    1. Bouras EP, Delgado-Aros S, Camilleri M, Castillo EJ, Burton DD, Thomforde GM, Chial HJ. SPECT imaging of the stomach: comparison with barostat and effects of sex, age, body mass index, and fundoplication. Gut. 2002;51:781–786. - PMC - PubMed
    1. Bredenoord AJ, Chial HJ, Camilleri M, Mullan BP, Murray JA. Gastric accommodation and emptying in evaluation of patients with upper gastrointestinal symptoms. Clin Gastroenterol Hepatol. 2003;1:264–272. - PubMed
    1. Vazquez Roque MI, Camilleri M, Stephens DA, Jensen MD, Burton DD, Baxter KL, Zinsmeister AR. Gastric sensorimotor functions and hormone profile in normal weight, overweight and obese people. Gastroenterology. 2006;131:1717–1724. - PubMed
    1. Liau S-S, Camilleri M, Kim D-Y, Stephens D, Burton DD, O’Connor MK. Pharmacological modulation of human gastric volumes demonstrated noninvasively using SPECT imaging. Neurogastroenterol Motil. 2001;13:533–542. - PubMed

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