Transition of endothelium to cartilage and bone
- PMID: 21211778
- DOI: 10.1016/j.stem.2010.12.004
Transition of endothelium to cartilage and bone
Abstract
Mesenchymal stromal cells (MSCs) are capable of differentiating into bone-forming osteoblasts. A recent Nature Medicine study (Medici et al., 2010) shows that the mislocalized bone in the human disease fibrodisplasia ossificans progressiva (FOP) originates from vascular endothelium that gives rise to MSCs.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment on
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Conversion of vascular endothelial cells into multipotent stem-like cells.Nat Med. 2010 Dec;16(12):1400-6. doi: 10.1038/nm.2252. Epub 2010 Nov 21. Nat Med. 2010. PMID: 21102460 Free PMC article.
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