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Case Reports
. 2011 Jan;84(1):107-8.
doi: 10.4269/ajtmh.2011.10-0291.

Case report: Expansion of visceral leishmaniasis to the western hilly part of Nepal

Basu Dev Pandey  1 , Sher Bahadur Pun, Osamu Kaneko, Kishor Pandey, Kenji Hirayama
Affiliations
Case Reports

Case report: Expansion of visceral leishmaniasis to the western hilly part of Nepal

Basu Dev Pandey et al. Am J Trop Med Hyg. 2011 Jan.

Abstract

We report the first case of visceral leishmaniasis (VL) from the non-endemic western hilly region of Nepal. The patient presented with a history of high-grade fever, abdominal distension, anemia, and weight loss. The case was confirmed as VL by microscopical detection of the Leishmania species amastigote in bone marrow aspiration and by a positive result for the rK39 test. The patient was treated with 0.5-1.0 mg/kg of Amphotericin B for 14 days (total of 405 mg), and amastigotes were negative on discharge. Five months later, this patient again developed fever, abdominal distension, and anemia. Clinical and hematological examinations suggested a relapse of VL. The patient was treated with 1 mg/kg of Amphotericin B for 18 days (total of 515 mg) and was clinically improved on discharge.

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Figures

Figure 1.
Figure 1.
District maps of Nepal. Districts endemic for leishmaniasis are indicated in grey. The VL patient reported resides in the hilly district Doti (black). The Bardiya district, where a suspected miltefosine-resistant VL case was previously reported, is indicated (black). STIDH indicates the Sukraraj Tropical and Infectious Disease Hospital.
See this image and copyright information in PMC

Comment in

References

    1. Pandey K, Pant S, Kanbara H, Shuaibu MN, Mallik AK, Pandey BD, Kaneko O, Yanagi T. Molecular detection of Leishmania parasites from whole bodies of sandflies collected in Nepal. Parasitol Res. 2008;108:293–297. - PubMed
    1. World Health Organization . Regional technical advisory group on kala-azar elimination. New Delhi, India: 2005. Proceedings of the 1st Meeting, December 20–23, 2004.
    1. Department of Health Sciences . Annual Report on Nepal. Kathmandu, Nepal: 2007. pp. 145–148.
    1. Rijal S, Chappuis F, Singh R, Bovier PA, Acharya P, Karki BM, Das ML, Desjues P, Loutan L, Koirala S. Treatment of visceral leishmaniasis in south-eastern Nepal: decreasing efficacy of sodium stiboglucanate and need for the policy to limit further decline. Trans R Soc Trop Med Hyg. 2003;97:350–354. - PubMed
    1. Joshi S, Bajracharya BL, Baral MR. Kala-azar (visceral leishmaniasis) from Khotang. Kathmandu Univ Med J. 2006;4:232–234. - PubMed

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