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Controlled Clinical Trial
. 2011 Jan;84(1):137-40.
doi: 10.4269/ajtmh.2011.09-0723.

Confirmed vivax resistance to chloroquine and effectiveness of artemether-lumefantrine for the treatment of vivax malaria in Ethiopia

Ambachew M Yohannes  1 , Awash Teklehaimanot, Yngve Bergqvist, Pascal Ringwald
Affiliations
Controlled Clinical Trial

Confirmed vivax resistance to chloroquine and effectiveness of artemether-lumefantrine for the treatment of vivax malaria in Ethiopia

Ambachew M Yohannes et al. Am J Trop Med Hyg. 2011 Jan.

Abstract

Chloroquine (CQ) is still the drug of choice for the treatment of vivax malaria in Ethiopia, whereas artemether-lumefantrine (AL) is for falciparum malaria. In this setting, clinical malaria cases are treated with AL. This necessitated the need to assess the effectiveness of AL for the treatment of Plasmodium vivax with CQ as a comparator. A total of 57 (80.3%) and 75 (85.2%) cases treated with CQ or AL, respectively, completed the study in an outpatient setting. At the end of the follow-up period of 28 days, a cumulative incidence of treatment failure of 7.5% (95% confidence interval [CI] = 2.9-18.9%) for CQ and 19% (95% CI = 11-31.6%) for AL was detected. CQ resistance was confirmed in three of five CQ treatment failures cases. The effectiveness of AL seems lower than CQ; however, the findings were not conclusive, because the AL evening doses were not supervised.

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References

    1. Ghebreyesus T, Deressa W. In: Epidemiology and Ecology of Health and Disease in Ethiopia. Berhane Y, Hailemariam D, Kloos H, editors. Addis Ababa, Ethiopia: Shama Books; 2006. pp. 556–576. (Malaria).
    1. Federal Ministry of Health of Ethiopia National Strategic Plan for Malaria Prevention and Control in Ethiopia 2001–2005. 2001. http://www.moh.gov.et/index.php Available at. Accessed May 15, 2009.
    1. Federal Ministry of Health of Ethiopia Malaria Diagnosis and Treatment Guidelines for Health Workers in Ethiopia. 2nd ed. 2004. http://www.moh.gov.et/index.php Available at. Accessed May 15, 2009.
    1. Daddi J, Gezahegn T, Ambachew M, Asnakew K, Daniel A, Olusegun B. Therapeutic efficacy of sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in Ethiopia. East Afr Med J. 2005;82:391–395. - PubMed
    1. Teklehaimanot A. Chloroquine-resistant Plasmodium falciparum malaria in Ethiopia. Lancet. 1996;328:127–129. - PubMed

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