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Comparative Study
. 2011;34(1):164-6.
doi: 10.1248/bpb.34.164.

Carrageenan gels for oral sustained delivery of acetaminophen to dysphagic patients

Shozo Miyazaki  1 , Mariko Ishitani, Akie Takahashi, Tetsuya Shimoyama, Kunihiko Itoh, David Attwood
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Free article
Comparative Study

Carrageenan gels for oral sustained delivery of acetaminophen to dysphagic patients

Shozo Miyazaki et al. Biol Pharm Bull. 2011.
Free article

Abstract

We have designed gel formulations for the oral administration of acetaminophen with suitable rheological characteristics for ease of administration to patients with swallowing difficulties and sufficient integrity in the stomach to achieve a sustained release of this drug. Gels formed by agar and ι-carrageenan were assessed for suitable gel strength and in vitro and in vivo release characteristics. Comparison of 1.5% ι-carrageenan gel with 0.5% agar gel demonstrated improved sustained release properties of the ι-carrageenan gel. Gel formed by ι-carrageenan has suitable rheological and sustained release characteristics for potential use as vehicles for oral delivery of drugs to dysphagic patients.

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