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Comment
. 2011 Jan;11(1):2.
doi: 10.1038/nrc2990.

Therapy: Multiple bypass problem for BRAF inhibition

Darren J Burgess
Comment

Therapy: Multiple bypass problem for BRAF inhibition

Darren J Burgess. Nat Rev Cancer. 2011 Jan.
No abstract available

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  • COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.
    Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA, Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, Vidal M, Zhao JJ, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE, Finan PM, Root DE, Roberts TM, Golub T, Flaherty KT, Dummer R, Weber BL, Sellers WR, Schlegel R, Wargo JA, Hahn WC, Garraway LA. Johannessen CM, et al. Nature. 2010 Dec 16;468(7326):968-72. doi: 10.1038/nature09627. Epub 2010 Nov 24. Nature. 2010. PMID: 21107320 Free PMC article.
  • Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation.
    Nazarian R, Shi H, Wang Q, Kong X, Koya RC, Lee H, Chen Z, Lee MK, Attar N, Sazegar H, Chodon T, Nelson SF, McArthur G, Sosman JA, Ribas A, Lo RS. Nazarian R, et al. Nature. 2010 Dec 16;468(7326):973-7. doi: 10.1038/nature09626. Epub 2010 Nov 24. Nature. 2010. PMID: 21107323 Free PMC article.

References

    1. Nature. 2010 Dec 16;468(7326):968-72 - PubMed
    1. Nature. 2010 Dec 16;468(7326):973-7 - PubMed

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