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. 2011 May;95(6):2140-2.
doi: 10.1016/j.fertnstert.2010.12.018. Epub 2011 Jan 7.

Blastocyst culture is associated with an elevated incidence of monozygotic twinning after single embryo transfer

Satoshi Kawachiya  1 , Daniel Bodri, Naoko Shimada, Keiichi Kato, Yuji Takehara, Osamu Kato
Affiliations

Blastocyst culture is associated with an elevated incidence of monozygotic twinning after single embryo transfer

Satoshi Kawachiya et al. Fertil Steril. 2011 May.

Abstract

In a 7-year (2002-2008) retrospective study of a large IVF program based on minimal ovarian stimulation and single ET (47,841 single ETs), monozygotic twinning occurred in 1.01% of 14,956 clinical pregnancies. Blastocyst culture was associated with a significantly increased monozygotic twinning risk (adjusted odds ratio, 2.04; 95% confidence interval, 1.29-4.48), whereas embryo freezing, type of stimulation protocol used, intracytoplasmic sperm injection fertilization, or zona removal did not influence its incidence.

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Comment in

  • Blastocyst culture and MZT after SET.
    Dessolle L, Fréour T. Dessolle L, et al. Fertil Steril. 2011 Jun;95(7):e41; author reply e42. doi: 10.1016/j.fertnstert.2011.03.055. Epub 2011 Apr 9. Fertil Steril. 2011. PMID: 21481378 No abstract available.

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