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. 2011 Apr;233(1-2):211-5.
doi: 10.1016/j.jneuroim.2010.11.010. Epub 2011 Jan 6.

Enhanced complement consumption in neuromyelitis optica and Behçet's disease patients

Erdem Tüzün  1 , Murat Kürtüncü, Recai Türkoğlu, Sema Içöz, Münevver Pehlivan, Omer Birişik, Mefküre Eraksoy, Gulsen Akman-Demir
Affiliations

Enhanced complement consumption in neuromyelitis optica and Behçet's disease patients

Erdem Tüzün et al. J Neuroimmunol. 2011 Apr.

Abstract

The complement system is essential in the pathogenesis of inflammatory central nervous system disorders. To investigate the involvement of complement pathways in neuromyelitis optica (NMO), levels of breakdown products for classical (C4d), alternative (FBb) and common (sC5b-9) pathways were measured in the sera of 28 NMO and control patients (30 Behçet's disease (BD), 29 multiple sclerosis (MS)) and 31 healthy controls by ELISA. Classical and/or alternative pathway consumption was enhanced in NMO and BD patients as compared to MS patients and healthy controls. Our results suggest that NBD and NMO differ from MS by the predominance of complement system involvement.

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