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. 2011 Jan 15;19(2):749-53.
doi: 10.1016/j.bmc.2010.12.025. Epub 2010 Dec 13.

Lyconadins D and E, and complanadine E, new Lycopodium alkaloids from Lycopodium complanatum

Kan'ichiro Ishiuchi  1 , Takaaki Kubota, Haruaki Ishiyama, Shigeki Hayashi, Toshiro Shibata, Koichiro Mori, Yutaro Obara, Norimichi Nakahata, Jun'ichi Kobayashi
Affiliations

Lyconadins D and E, and complanadine E, new Lycopodium alkaloids from Lycopodium complanatum

Kan'ichiro Ishiuchi et al. Bioorg Med Chem. .

Abstract

Three new Lycopodium alkaloids, lyconadins D (1) and E (2), and complanadine E (3), were isolated from the club moss Lycopodium complanatum. Lyconadin D (1) was the first example of fastigiatine-type alkaloid isolated from Lycopodium complanatum. The structures and relative stereochemistry of 1-3 were elucidated on the basis of spectroscopic data. Complanadine E (3) enhanced mRNA expression for NGF.

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