Axon guidance: push and pull with ephrins and GDNF
- PMID: 21215934
- DOI: 10.1016/j.cub.2010.11.064
Axon guidance: push and pull with ephrins and GDNF
Abstract
The pathfinding of motor axons is an important model system for understanding binary axon guidance decisions. Recent work has shown that GDNF attracts motor neuron growth cones, and interacts synergistically with ephrinAs on growth cone directionality.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Comment on
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GDNF acts as a chemoattractant to support ephrinA-induced repulsion of limb motor axons.Curr Biol. 2010 Dec 7;20(23):2150-6. doi: 10.1016/j.cub.2010.11.021. Epub 2010 Nov 25. Curr Biol. 2010. PMID: 21109439
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