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. 2008 Jun;1(1):18-21.
doi: 10.2478/v10102-010-0026-y.

The present approaches to the development of prophylactic and therapeutic antidotes against nerve agents

Jiří Kassa  1 , Jiří Bajgar, Kamil Kuča, Kamil Musílek, Jana Karasová
Affiliations

The present approaches to the development of prophylactic and therapeutic antidotes against nerve agents

Jiří Kassa et al. Interdiscip Toxicol. 2008 Jun.
No abstract available

Keywords: acetylcholinesterase; antidote; nerve agent; organophosphates; prophylaxis; therapy.

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References

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    1. Bajgar J, Fusek J, Jun D, Kuca K, Bartosova L. Possibility of pharmacological prophylaxis against highly toxic organophosphates. Chem Listy. 2007a;101:81–83.
    1. Bajgar J, Hajek P, Karasova J, Slizova D, Krs O, Kuca K, Jun D, Fusek J, Capek L. Inhibition of acetylcholinesterase in different structures of the rat brain following soman intoxication pretreated with Huperzine A. Int J Mol Sci. 2007b;8:1165–1176.
    1. Bajgar J, Bartosova L, Kuca K, Jun D, Fusek J. Changes in cholinesterase activities in the rat blood and brain after sarin intoxication pretreated with butyrylcholinesterase. Drug Chem Toxicol. 2007c;30:351–359. - PubMed
    1. Clement JG, Hansen AS, Boulet CA. Efficacy of HLö-7 and pyrimidoxime as antidotes of nerve agent poisoning in mice. Arch Toxicol. 1992;66:216–219. - PubMed

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