Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Feb;62(2):140-3.
doi: 10.1177/0003319710385335.

The role of the CCR2 gene polymorphism in abdominal aortic aneurysms

Nurkay Katrancioglu  1 , Sinasi Manduz, Oguz Karahan, Mehmet Birhan Yilmaz, Ilhan Sezgin, Gokhan Bagci, Ocal Berkan
Affiliations

The role of the CCR2 gene polymorphism in abdominal aortic aneurysms

Nurkay Katrancioglu et al. Angiology. 2011 Feb.

Abstract

Objective: Chronic inflammation play an important role on abdominal aortic aneurysms (AAA) formation. Chemokine receptor-2 (CCR2) is involved in regulation of the inflammatory response. However, relation between CCR2 polymorphism and AAA formation in human has not yet been investigated. In this study, we aimed to investigate the relationship between AAA and CCR2-V64I gene polymorphism.

Methods: In this study, 100 consecutive patients with AAA and 138 individuals with normal aortic diameter were included. CCR2-V64I gene polymorphism were analyzed by PCR-RFLP technique. Genotype distribution and allele frequencies of CCR2-V64I gene polymorphism in patients with AAA and healthy subjects were compared.

Results: CCR2 heterozygote V64I polymorphism and allele frequency were more frequently observed in the AAA group (p = 0.01, p = 0.004). Significant relationship was observed between CCR2 V64I polymorphism (OR:2.31, 95% CI:1.19-4.46, p = 0.01) and presence of AAA in multivariate regression analysis.

Conclusion: The present study, showed us a relationship between CCR2-V64I polymorphism and AAA.

PubMed Disclaimer

LinkOut - more resources