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Review
. 2011 Mar;5(1):31-5.
doi: 10.1007/s12105-010-0235-x. Epub 2011 Jan 8.

A review of NUT midline carcinoma

Edward B Stelow  1
Affiliations
Review

A review of NUT midline carcinoma

Edward B Stelow. Head Neck Pathol. 2011 Mar.

Abstract

Nut midline carcinomas are uncommon carcinomas characterized by chromosomal rearrangements that involve the gene encoding the nuclear protein of the testis (NUT). This article reviews the clinicopathologic features of these malignancies. Ancillary testing is discussed as well as the pathologic differential diagnosis.

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Figures

Fig. 1
Fig. 1
A NUT midline carcinoma composed of sheets of undifferentiated cells immediately beneath metaplastic squamous epithelium of the larynx
Fig. 2
Fig. 2
A sinonasal NUT midline carcinoma with infiltrating trabeculae of undifferentiated cells separated by desmoplastic stroma
Fig. 3
Fig. 3
A NUT midline carcinoma with abrupt squamous differentiation
Fig. 4
Fig. 4
This aspirate of a metastatic NUT midline carcinoma contains cohesive clusters of poorly differentiated epithelial cells
See this image and copyright information in PMC

References

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