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. 2011 Feb 18;13(4):592-5.
doi: 10.1021/ol1027865. Epub 2011 Jan 11.

Cooperative catalytic reactions using organocatalysts and transition metal catalysts: enantioselective propargylic alkylation of propargylic esters with aldehydes

Akiko Yoshida  1 , Masahiro Ikeda, Gaku Hattori, Yoshihiro Miyake, Yoshiaki Nishibayashi
Affiliations

Cooperative catalytic reactions using organocatalysts and transition metal catalysts: enantioselective propargylic alkylation of propargylic esters with aldehydes

Akiko Yoshida et al. Org Lett. .

Abstract

The enantioselective propargylic alkylation of propargylic esters with aldehydes in the presence of a copper complex and an optically active secondary amine as cocatalysts has been found to give the corresponding propargylic alkylated products in good yields as a mixture of two diastereoisomers with a high enantioselectivity.

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