Review
doi: 10.1016/0168-9525(90)90207-m.
Yeast artificial chromosomes: tools for mapping and analysis of complex genomes
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- PMID: 2122561
- DOI: 10.1016/0168-9525(90)90207-m
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Review
Yeast artificial chromosomes: tools for mapping and analysis of complex genomes
Trends Genet.
1990 Aug.
Abstract
Libraries of yeast artificial chromosomes (YACs) are representative of complex genomes, and typical YACs contain single fragments of DNA that are up to a megabase or more in size, are stable during growth, and are faithful to genomic DNA. Such YACs may permit (1) the use of complete gene units for a number of research and medical purposes; and (2) the assembly of chromosome-sized contigs in a single map that unifies genetic and physical data.
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