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. 2011 Apr;69(4):656-62.
doi: 10.1016/j.apradiso.2010.12.012. Epub 2010 Dec 25.

Questioning the value of (99m)Tc-HYNIC-annexin V based response monitoring after docetaxel treatment in a mouse model for hereditary breast cancer

Chantal A C Beekman  1 , Tessa Buckle, Anne C van Leeuwen, Renato A Valdés Olmos, Marcel Verheij, Sven Rottenberg, Fijs W B van Leeuwen
Affiliations

Questioning the value of (99m)Tc-HYNIC-annexin V based response monitoring after docetaxel treatment in a mouse model for hereditary breast cancer

Chantal A C Beekman et al. Appl Radiat Isot. 2011 Apr.

Abstract

Annexin V imaging is suggested to provide a good indication of cancer treatment efficacy. To study the accuracy of (99m)Tc-AnxV imaging, we monitored chemo-sensitive and chemo-resistant tumors in a mouse breast cancer model after treatment with docetaxel. Sensitive tumors showed a slight peak in (99m)Tc-AnxV uptake one day post-treatment, while uptake in resistant tumors remained constant. In contrast to immunohistochemical analysis, (99m)Tc-AnxV imaging could not be used to predict tumor response, due to large variation between animals.

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