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Meta-Analysis
. 2011 Jul;137(7):1085-93.
doi: 10.1007/s00432-010-0972-y. Epub 2011 Jan 13.

18F-FDG PET or PET-CT to evaluate prognosis for head and neck cancer: a meta-analysis

Peng Xie  1 , Minghuan Li, Hanxi Zhao, Xindong Sun, Zheng Fu, Jinming Yu
Affiliations
Meta-Analysis

18F-FDG PET or PET-CT to evaluate prognosis for head and neck cancer: a meta-analysis

Peng Xie et al. J Cancer Res Clin Oncol. 2011 Jul.

Abstract

Purpose: The purpose of this meta-analysis was to evaluate the prognostic value of standard uptake value (SUV) from serial Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) in patients with head and neck cancer.

Methods: We searched for articles limited to head and neck cancer, dealt with the impact of SUV on survival and published in English. The endpoints were disease-free survival (DFS), overall survival (OS), and local control (LC). Two reviewers extracted data independently.

Results: Thirty-five studies were identified; of which, 26 studies involving 1,415 patients met the inclusion criteria. Pooled survival data suggested better DFS, OS, and LC in patients with low SUV of pre-treatment, and the odds ratio (OR) was 0.23, 0.24, and 0.27, respectively. Patients having tumors with low SUV of post-treatment also had significantly better DFS (OR = 0.17) and OS (OR = 0.28) than those with high SUV.

Conclusions: The present meta-analysis showed that (18)F-FDG uptake, as measured by the SUV before treatment and metabolic response after treatment, are valuable for predicting long-term survival in head and neck cancer. High (18)F-FDG uptake may be useful for identifying patients requiring more aggressive treatment.

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Conflict of interest statement

There is no conflict of interest among authors.

Figures

Fig. 1
Fig. 1
The study selection procedure of meta-analysis
Fig. 2
Fig. 2
Meta-analysis of 9 studies dealt with the predictive value of pre-treatment SUV for DFS
Fig. 3
Fig. 3
Meta-analysis of 12 studies dealt with the predictive value of pre-treatment SUV for OS
Fig. 4
Fig. 4
Meta-analysis of 8 studies dealt with the predictive value of pre-treatment SUV for LC
Fig. 5
Fig. 5
Meta-analysis of 5 studies dealt with the predictive value of post-treatment SUV for DFS
Fig. 6
Fig. 6
Meta-analysis of 5 studies dealt with the predictive value of post-treatment SUV for OS
See this image and copyright information in PMC

References

    1. Allal AS, Dulguerov P, Allaoua M et al (2002) Standardized uptake value of 2-[18F] fluoro-2-deoxy-d-glucose in predicting outcome in head and neck carcinomas treated by radiotherapy with or without chemotherapy. J Clin Oncol 20(5):1398–1404 - PubMed
    1. Allal AS, Slosman DO, Kebdani T et al (2004) Prediction of outcome in head-and-neck cancer patients using the standardized uptake value of 2-[18F]fluoro-2-deoxy-d-glucose. Int J Radiat Oncol Biol Phys 59(5):1295–1300 - PubMed
    1. Bernier J, Domenge C, Ozsahin M et al (2004) Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med 350(19):1945–1952 - PubMed
    1. Bonner JA, Harari PM, Giralt J et al (2006) Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 354(6):567–578 - PubMed
    1. Brun E, Kjellén E, Tennvall J et al (2002) FDG PET studies during treatment: prediction of therapy outcome in head and neck squamous cell carcinoma. Head Neck 24(2):127–135 - PubMed

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