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. 2011 Feb 1;21(3):971-6.
doi: 10.1016/j.bmcl.2010.12.048. Epub 2010 Dec 21.

New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones

Andrés A Trabanco  1 , Guillaume Duvey, José María Cid, Gregor J Macdonald, Philippe Cluzeau, Vanthea Nhem, Rocco Furnari, Nadia Behaj, Géraldine Poulain, Terry Finn, Hilde Lavreysen, Sonia Poli, Alexandre Raux, Yves Thollon, Nicolas Poirier, David D'Addona, José Ignacio Andrés, Robert Lutjens, Emmanuel Le Poul, Hassan Imogai, Jean-Philippe Rocher
Affiliations

New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones

Andrés A Trabanco et al. Bioorg Med Chem Lett. .

Abstract

A series of N-propyl-8-chloro-6-substituted isoquinolones was identified as positive allosteric modulators of metabotropic glutamate receptor 2 (mGluR2 PAM) via high throughput screening (HTS). The subsequent synthesis and initial SAR exploration that led to the identification of compound 28 is described.

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