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. 2010 Fall;12(4):e197-201.

Neuroendocrine tumor of the bladder

Shailen S Sehgal, Alan J Wein, Zhanyong Bing, S Bruce Malkowicz, Thomas J Guzzo

Neuroendocrine tumor of the bladder

Shailen S Sehgal et al. Rev Urol. 2010 Fall.

Abstract

Small cell carcinoma (SCC) of the bladder is a rare and aggressive tumor associated with a poor prognosis. It often presents at a later stage than urothelial carcinoma of the bladder, and comprises less than 1% of bladder malignancies. A number of treatment algorithms have been used to treat bladder SCC, including cystectomy, partial cystectomy, radiotherapy, chemoradiotherapy, chemotherapy alone, and neoadjuvant/adjuvant chemotherapy. Presented is a case of SCC of the bladder, and the epidemiology, prognosis, and current treatment algorithms for patients with bladder SCC are reviewed.

Keywords: Bladder cancer; Neuroendocrine tumors; Small cell carcinoma.

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Figures

Figure 1
Figure 1
(A) Liver metastases and (B) bladder mass on T2-weighted magnetic resonance imaging.
Figure 2
Figure 2
Pathologic specimen from transurethral resection. On hematoxylin and eosin stains, the tumor shows (A) sheets of poorly differentiated cells (×200) with (B) high nuclear and cytoplasm ratio (× 400). However, the tumor cells have more abundant cytoplasm than the classic small cell carcinoma (SCC). Immunohistochemical stains show that the tumor is (C) positive for cytokeratin (AE1/3) and (D) focally positive for synaptophysin.
See this image and copyright information in PMC

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