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. 2011:2011:509036.
doi: 10.1155/2011/509036. Epub 2010 Dec 29.

Impact of HPV in Oropharyngeal Cancer

Linda Marklund  1 , Lalle Hammarstedt
Affiliations

Impact of HPV in Oropharyngeal Cancer

Linda Marklund et al. J Oncol. 2011.

Abstract

The incidence of oropharyngeal cancers has increased in the western world and Human Papilloma Virus (HPV) has been recognised as a risk factor in the last decades. During the same period the prevalence of HPV in oropharyngeal tumours has increased and HPV has been suggested responsible for the increase. The HPV-positive tumours are today recognized as a distinct subset of head and neck cancers with its own clinopathological and risk profile and have a significantly improved prognosis regardless of treatment strategy. This review summarizes current knowledge regarding human papillomavirus biology, oncogenic mechanisms, risk factors, and impact of treatment.

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