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. 2010:2010:546854.
doi: 10.1155/2010/546854. Epub 2010 Dec 27.

IGF-I and IGF Binding Protein-3 Generation Tests and Response to Growth Hormone in Children with Silver-Russell Syndrome

Izabel C R Beserra  1 , Márcia G Ribeiro, Paulo F Collett-Solberg, Mário Vaisman, Marília M Guimarães
Affiliations

IGF-I and IGF Binding Protein-3 Generation Tests and Response to Growth Hormone in Children with Silver-Russell Syndrome

Izabel C R Beserra et al. Int J Pediatr Endocrinol. 2010.

Abstract

Objectives. To evaluate, in children with Silver-Russell Syndrome, the response to the IGF-I and IGFBP-3 generation test and compare results to the growth response after 6 months of rhGH. Methods. Eight children (6 males), with a mean age of 5.71 ± 2.48 years and height SDS of -3.88 ± 1.28 received rhGH for 6 months. IGF-I and IGFBP-3 were analyzed before and after 4 doses of rhGH. Results. The mean growth velocity (GV) before treatment was 5.28 ± 1.9 cm/year. GV increased after rhGH in five children to a mean GV of 10.3 ± 3.64 cm/year. Six children had normal basal IGF-I levels and two low levels. After 4 doses of rhGH, the IGF-I levels were normal in seven. There was no correlation between the growth response and the IGF-I generation test. Conclusions. Children with SRS have normal IGF-I generation test. There is no correlation between the generation test and the growth velocity after 6 months of rhGH.

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Figures

Figure 1
Figure 1
Growth velocities before and after 6 months of treatment.
Figure 2
Figure 2
IGF-I values before and after 4 doses of rhGH.
Figure 3
Figure 3
Correlation between the IGF-I generation test and the change in growth velocity.
Figure 4
Figure 4
IGFBP-3 values before and after 4 doses of rhGH.
Figure 5
Figure 5
Correlation between the IGFBP-3 generation test and the change in growth velocity.
See this image and copyright information in PMC

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