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. 2010 Oct;149(4):466-70.
doi: 10.1007/s10517-010-0972-6.

Morphofunctional analysis of experimental model of esophageal achalasia in rats

[Article in English, Russian]
A G Sabirov  1 , I S Raginov, M V Burmistrov, Y A Chelyshev, R Sh Khasanov, A A Moroshek, P N Grigoriev, A L Zefirov, M A Mukhamedyarov
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Morphofunctional analysis of experimental model of esophageal achalasia in rats

[Article in English, Russian]
A G Sabirov et al. Bull Exp Biol Med. 2010 Oct.

Abstract

We carried out a detailed analysis of rat model of esophageal achalasia previously developed by us. Manifest morphological and functional disorders were observed in experimental achalasia: hyperplasia of the squamous epithelium, reduced number of nerve fibers, excessive growth of fibrous connective tissue in the esophageal wall, high contractile activity of the lower esophageal sphincter, and reduced motility of the longitudinal muscle layer. Changes in rat esophagus observed in experimental achalasia largely correlate with those in esophageal achalasia in humans. Hence, our experimental model can be used for the development of new methods of disease treatment.

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