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. 2011 Aug;19(8):1316-9.
doi: 10.1007/s00167-010-1356-1. Epub 2011 Jan 14.

The treatment of chondral and osteochondral defects of the knee with autologous matrix-induced chondrogenesis (AMIC): method description and recent developments

Jan Philipp Benthien  1 , Peter Behrens
Affiliations

The treatment of chondral and osteochondral defects of the knee with autologous matrix-induced chondrogenesis (AMIC): method description and recent developments

Jan Philipp Benthien et al. Knee Surg Sports Traumatol Arthrosc. 2011 Aug.

Abstract

Purpose: Articular resurfacing by treatment of chondral defects may include chondral abrasion, autologous chondrocyte Implantation (ACI), matrix-induced chondrocyte transplantation (MACT) or osteochondral autologous transplantation (OATS). This technical note describes the method of autologous matrix-induced chondrogenesis (AMIC), a one-step procedure combining subchondral microfracture with the fixation of a collagen I/III membrane with fibrin glue or sutures.

Methods: This is a technical note on the AMIC procedure and its further development.

Results and conclusion: This method is applied primarily in chondral or osteochondral lesions of the knee. Indications and contraindications are provided; the technique is described. The further development of AMIC is described with an increased focus on the subchondral zone and the complex of cartilage and bone, the osteochondral unit, which receives increased attention in cartilage research.

Level of evidence: IV.

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