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Comment
. 2011 Jan;43(1):21-5.
doi: 10.1055/s-0030-1256021. Epub 2011 Jan 13.

Reflux and Barrett's disease

S D Crockett  1 , N J Shaheen
Affiliations
Comment

Reflux and Barrett's disease

S D Crockett et al. Endoscopy. 2011 Jan.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Competing interests: Dr Shaheen has served as a consultant to Astra Zeneca and CSA Medical, and has received research support from Astra Zeneca, Takeda, Procter & Gamble, BARRX Medical, CSA Medical, and Oncoscope.

Figures

Fig. 1
Fig. 1
Endoscopic polarized scanning spectroscopy (EPSS) of Barrett’s esophagus. a Illustration of probe inserted into working channel of upper endoscope with yellow arrows indicating linear rise of probe tip before each scan and rotary motion during scanning. bEndoscopic image showing actual EPSS probe during scanning of Barrett’s esophagus segment showing illumination spot on the esophageal wall at the upper right of the image. (Reproduced with permission from Macmillan Publishers Ltd. ©2010. Qui et al., Nat Med 2010; 16: 603–606.)
Fig. 2
Fig. 2
Pseudocolor maps produced from endoscopic polarized scanning spectroscopy (EPSS) data overlaid with circles indicating biopsy sites and confirmed pathology. Vertical axis indicates the angle of rotation from the start of each rotary scan, and the horizontal axis indicates distance from upper incisors. Blue and green areas are sites unlikely for dysplasia, and pink/red areas are sites suspicious for dysplasia as determined by EPSS. Color of circles indicates pathology results (green, nondysplastic; pink, low grade dysplasia; red, high grade dysplasia). The two images depicted represent one patient whose initial exam was negative for dysplasia based on standard-of-care 4-quadrant biopsies (i.e. all green circles) but whose EPSS map identified several areas suspicious for dysplasia (pink and red areas). The patient was recalled and three EPSS-guided biopsies confirmed high grade dysplasia. (Reproduced with permission from Macmillan Publishers Ltd. ©2010. Qui et al., Nat Med 2010; 16: 603–606.)
Fig. 3
Fig. 3
Overall and cancer-free survival from Prasad et al., in patients treated with esophagectomy (gray lines) and with endoscopic mucosal resection (EMR) (black lines). Kaplan-Meier curves show superior cancer-free survival in the esophagectomy group compared with the EMR group (right panel), but similar overall survival in the two groups (left panel). (Reproduced with permission from Elsevier. Prasad et al., Gastroenterology 2009; 137: 815–823.)
Fig. 4
Fig. 4
Kaplan–Meier curve demonstrating cumulative rate of progression to high grade dysplasia (HGD) or cancer (Ca) for the entire cohort, and those with low grade dysplasia (LGD), indefinite dysplasia (ID), and nondysplastic Barrett’s esophagus (NDBE). (Reproduced with permission from Macmillan Publishers Ltd. ©2010. Curvers et al., Am J Gastroenterol 2010; 105: 1523–1530.)
Fig. 5
Fig. 5
Endoscopic images from an endoscopic spray cryotherapy session. a Dual-channel decompression tube in place with a friction-fit cap before administration of liquid nitrogen therapy. b Postcryotherapy image demonstrating white frost on the targeted dysplastic mucosa. (Reproduced with permission from Elsevier. Shaheen et al., Gastrointest Endosc 2010; 71: 680–685.)
Fig. 6
Fig. 6
Box plot showing change in median globus score before (blue) and after (green) therapy in each study arm of a trial of argon plasma coagulation (APC) ablation of cervical inlet patches for treatment of globus sensation. (Reproduced with permission from Elsevier. Bajbouj et al., Gastroenterology 2009; 137: 440–444.)
See this image and copyright information in PMC

Comment on

References

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