Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Oct;5(10):1507-10.

A variety of tumours induced by the middle T antigen of polyoma virus in a transgenic mouse family

M Rassoulzadegan  1 , S A Courtneidge, R Loubière, P el Baze, F Cuzin
Affiliations
  • PMID: 2123530

A variety of tumours induced by the middle T antigen of polyoma virus in a transgenic mouse family

M Rassoulzadegan et al. Oncogene. 1990 Oct.

Abstract

A transgenic mouse family expressing the middle T antigen of polyoma virus under control of the immunoglobulin heavy chain (IgE) enhancer showed the frequent occurrence of carcinomas in various organs, predominantly in females. Most frequently affected were the salivary and thyroid glands, but mammary tumours, liver haemangiomas and adenocarcinomas of unknown origin were also observed. In all tumours, the middle T antigen was found to be complexed with cellular tyrosine kinases. These results extend the range of tumour types associated with in vivo expression of middle T and with the subsequent deregulation of pp60c-src and related tyrosine kinases.

PubMed Disclaimer

Publication types

Substances

LinkOut - more resources