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Comparative Study
. 1990 Dec;87(23):9148-52.
doi: 10.1073/pnas.87.23.9148.

cDNA clone encoding Drosophila transcription factor TFIID

M L Muhich  1 , C T Iida, M Horikoshi, R G Roeder, C S Parker
Affiliations
Comparative Study

cDNA clone encoding Drosophila transcription factor TFIID

M L Muhich et al. Proc Natl Acad Sci U S A. 1990 Dec.

Abstract

Proper initiation of transcription by RNA polymerase II requires the TATA-consensus-binding transcription factor TFIID. A cDNA clone encoding the Drosophila TFIID protein has been isolated and characterized. The deduced amino acid sequence reveals an open reading frame of 353 residues. The carboxyl-terminal 180 amino acids are approximately 80% identical to yeast TFIID and 88% identical to human TFIID. The amino-terminal portions of the yeast and Drosophila TFIID proteins lack appreciable homology, whereas the Drosophila and human amino termini appear qualitatively similar. In addition, the amino-terminal region of the Drosophila TFIID contains several sequence motifs that are found in other Drosophila proteins which appear to regulate transcription.

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References

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