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. 1992 Sep;7(9):295-9.
doi: 10.1016/0169-5347(92)90226-2.

The ecology and evolution of tetracycline resistance

R Johnson  1 , J Adams
Affiliations
Free article

The ecology and evolution of tetracycline resistance

R Johnson et al. Trends Ecol Evol. 1992 Sep.
Free article

Abstract

The use of tetracycline over the past few decades has been accompanied by a drastic increase in the frequency of tetracycline resistance in a wide range of bacterial species and genera. A diversity of resistance determinants is found in the microbial world, coding for markedly different mechanisms of resistance. The recent analysis of one family of resistance determinants provides evidence for intergenic and intragenic coevolutionary changes as well as for an unusual evolutionary history of duplication and divergence in function of domains within a single locus.

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