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. 2011 Jul 7;220(2):338-43.
doi: 10.1016/j.bbr.2011.01.005. Epub 2011 Jan 14.

Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation

Mar Cuadrado-Tejedor  1 , Ana Ricobaraza, Joaquín Del Río, Diana Frechilla, Rafael Franco, Alberto Pérez-Mediavilla, Ana Garcia-Osta
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Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation

Mar Cuadrado-Tejedor et al. Behav Brain Res. .

Abstract

This study was undertaken to know whether cognition deficits produced by chronic mild stress (CMS) were associated with pathological markers of Alzheimer's disease (AD). The results show that the impairment in the Morris water maze test induced by CMS correlated with an increase in CDK5-dependent phospho-tau levels and with an increase in APP processing. Mice exposed to CMS may then constitute a non-transgenic model for sporadic forms of AD.

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