Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2011 Jan 20;9(1):1-2.
doi: 10.1016/j.chom.2011.01.002.

Understanding how hepatitis C virus builds its unctuous home

Brett D Lindenbach  1
Affiliations
Comment

Understanding how hepatitis C virus builds its unctuous home

Brett D Lindenbach. Cell Host Microbe. .

Abstract

Hepatitis C virus genome replication occurs in endoplasmic reticulum-derived membrane compartments, but it is unknown how these structures arise. In this issue of Cell Host & Microbe, Reiss and colleagues (2011) show that the virus recruits a specific lipid kinase to replication sites, stimulates its kinase activity, and alters the phospholipid profile of replication compartments.

PubMed Disclaimer

Figures

Figure 1
Figure 1. PI4KIIIα Is Needed for HCV Replication Complex Assembly
(A and B) HCV RNA replication is thought to take place within invaginations of an ER-derived membrane. The viral NS3-4A, NS4B, NS5A, and NS5B proteins are all essential for this process (A). NS5A binds and activates PI4KIII, leading to the local production of PI4P (B). One possibility is that PI4P then recruits viral or cellular factors that are essential for forming the replication compartment.
See this image and copyright information in PMC

Comment on

References

    1. Amako Y, Sarkeshik A, Hotta H, Yates J, 3rd, Siddiqui A. Role of oxysterol binding protein in hepatitis C virus infection. Journal of virology. 2009;83:9237–9246. - PMC - PubMed
    1. Berger KL, Cooper JD, Heaton NS, Yoon R, Oakland TE, Jordan TX, Mateu G, Grakoui A, Randall G. Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication. Proceedings of the National Academy of Sciences of the United States of America. 2009;106:7577–7582. - PMC - PubMed
    1. Borawski J, Troke P, Puyang X, Gibaja V, Zhao S, Mickanin C, Leighton-Davies J, Wilson CJ, Myer V, Cornellataracido I, et al. Class III phosphatidylinositol 4-kinase alpha and beta are novel host factor regulators of hepatitis C virus replication. Journal of virology. 2009;83:10058–10074. - PMC - PubMed
    1. Gao M, Nettles RE, Belema M, Snyder LB, Nguyen VN, Fridell RA, Serrano-Wu MH, Langley DR, Sun JH, O’Boyle DR, 2nd, et al. Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect. Nature. 2010;465:96–100. - PMC - PubMed
    1. Hsu NY, Ilnytska O, Belov G, Santiana M, Chen YH, Takvorian PM, Pau C, van der Schaar H, Kaushik-Basu N, Balla T, et al. Viral reorganization of the secretory pathway generates distinct organelles for RNA replication. Cell. 2010;141:799–811. - PMC - PubMed

LinkOut - more resources