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. 2011 Jun;158(6):941-6.
doi: 10.1016/j.jpeds.2010.12.007. Epub 2011 Jan 15.

The impact of in utero exposure to diabetes on childhood body mass index growth trajectories: the EPOCH study

Tessa L Crume  1 , Lorraine Ogden, Stephen Daniels, Richard F Hamman, Jill M Norris, Dana Dabelea
Affiliations

The impact of in utero exposure to diabetes on childhood body mass index growth trajectories: the EPOCH study

Tessa L Crume et al. J Pediatr. 2011 Jun.

Abstract

Objective: To examine associations between exposure to maternal diabetes in utero and body mass index (BMI) growth trajectories from birth through 13 years of age among a diverse cohort of youth.

Study design: Mixed linear effects models were constructed to assess differences in BMI and BMI growth velocity from birth through 13 years of age for 95 subjects exposed to diabetes in utero and 409 unexposed subjects enrolled in a retrospective cohort study.

Results: The overall BMI growth trajectory (adjusted for sex and race/ethnicity) was not significantly different for exposed and unexposed subjects from birth through 26 months of age (P = .48). However, the overall growth trajectory from 27 months of age through 13 years differed by exposure status (P = .008), adjusted for sex and race/ethnicity. The difference was primarily due to a significantly higher BMI growth velocity among exposed youth between 10 and 13 years, increasing by 4.56 kg/m² compared with 3.51 kg/m² in the unexposed (P = .005). Control for demographic variables, socioeconomic factors, and maternal prepregnancy BMI did not alter the observed associations.

Conclusions: Exposure to maternal diabetes in utero accelerates BMI growth in late childhood, thus increasing long-term obesity risk.

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Figures

Figure 1
Figure 1
Mean BMI curves for youth both exposed and unexposed to maternal diabetes in utero from birth - 26 months of age, adjusted for sex and race/ethnicity.
Figure 2
Figure 2
Mean BMI curves for youth both exposed and unexposed to maternal diabetes in utero from 27 months of age to 13 years, adjusted for sex, race/ethnicity.
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References

    1. Ebbeling CB, Pawlak DB, Ludwig DS. Childhood obesity: public-health crisis, common sense cure. Lancet. 2002;360:473–81. - PubMed
    1. Must A, Jacques P, Dallal G, Bajema CJ, Dietz WH. Long-term morbidity and mortality of overweight adolescents: a follow-up of the Harvard Growth Study of 1922 to 1935. New England Journal of Medicine. 1992;327:1350–56. - PubMed
    1. Haslam DW, James WP. Obesity. Lancet. 2005;366:1197–209. - PubMed
    1. Freinkel N. Of pregnancy and progeny (review). Banting Lecture 1980. Diabetes. 1980;29:1023–36. - PubMed
    1. Bergmann KE, Bergmann RL, Von Kries R, Böhm O, Richter R, Dudenhausen JW, et al. Early determinants of childhood overweight and adiposity in a birth cohort study: role of breast-feeding. Int J Obes Relat Metab Disord. 2003;27:162–72. - PubMed

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