Monoclonal tumor origin is an underlying misconception of the RESIC approach
- PMID: 21239682
- PMCID: PMC3033296
- DOI: 10.1073/pnas.1017998108
Monoclonal tumor origin is an underlying misconception of the RESIC approach
Conflict of interest statement
The author declares no conflict of interest.
Comment on
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A mathematical framework to determine the temporal sequence of somatic genetic events in cancer.Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17604-9. doi: 10.1073/pnas.1009117107. Epub 2010 Sep 23. Proc Natl Acad Sci U S A. 2010. PMID: 20864632 Free PMC article.
References
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- Parsons BL. Many different tumor types have polyclonal tumor origin: Evidence and implications. Mutat Res. 2008;659:232–247. - PubMed
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- Thirlwell C, et al. Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas. Gastroenterology. 2010;138:1441–1454. - PubMed
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- Parsons BL, et al. ACB-PCR quantification of K-RAS codon 12 GAT and GTT mutant fraction in colon tumor and non-tumor tissue. Cancer Invest. 2010;28:364–375. - PubMed
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