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. 2011 Apr;38(4):702-5.
doi: 10.3899/jrheum.100754. Epub 2011 Jan 15.

Antinuclear antibodies and clinical associations in a british cohort with limited cutaneous systemic sclerosis

Angela E Gliddon  1 , Caroline J Doré, Juliet Dunphy, Zoë Betteridge, Neil J McHugh, Peter J Maddison; QUINS Trial Study Group
Collaborators, Affiliations

Antinuclear antibodies and clinical associations in a british cohort with limited cutaneous systemic sclerosis

Angela E Gliddon et al. J Rheumatol. 2011 Apr.

Abstract

Objective: To assess the prevalence of disease-specific autoantibodies in patients with limited cutaneous systemic sclerosis (lcSSc).

Methods: Sera from 180 patients with lcSSc were analyzed for antinuclear antibody (ANA). Clinical characteristics were compared in the presence or absence of specific autoantibodies.

Results: SSc-specific antibodies were detected in 135 patients (75%). Associations were found between anticentromere antibody and age at lcSSc diagnosis, telangiectasia, reduced creatinine clearance, and selective reduction in DLCO, and between antitopoisomerase-I and pulmonary fibrosis.

Conclusion: The majority of patients with lcSSc belong to distinctive serologic subsets, potentially with prognostic significance.

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