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Comment
. 2011 Jan 13;15(1):102.
doi: 10.1186/cc9372.

Is cortisol the key to the pathogenesis of delirium after coronary artery bypass graft surgery?

Jakub Kazmierski  1 , Iwona Kloszewska
Affiliations
Comment

Is cortisol the key to the pathogenesis of delirium after coronary artery bypass graft surgery?

Jakub Kazmierski et al. Crit Care. .

Abstract

Postoperative delirium is a serious complication of cardiac surgery. However, the pathophysiology of this mental syndrome is largely unknown. Recent findings suggest an association between elevated level of cortisol and postoperative delirium. Further studies should investigate the mechanisms responsible for excessive perioperative cortisol secretion.

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Comment on

References

    1. Mu D-L, Wang D-X, Li L-H, Shan G-J, Li J, Yu Q-J, Shi C-X. High serum cortisol level is associated with increased risk of delirium after coronary artery bypass graft surgery: a prospective cohort study. Crit Care. 2010;14:R238. - PMC - PubMed
    1. McIntosh TK, Bush HL, Yeston NS, Grasberger R, Palter M, Aun F, Egdahl RH. Beta-endorphin, cortisol and postoperative delirium: a preliminary report. Psychoneuroendocrinology. 1985;10:303–313. doi: 10.1016/0306-4530(85)90007-1. - DOI - PubMed
    1. Detroyer E, Dobbels F, Verfaillie E, Meyfroidt G, Sergeant P, Milisen K. Is preoperative anxiety and depression associated with onset of delirium after cardiac surgery in older patients? A prospective cohort study. J Am Geriatr Soc. 2008;56:2278–2284. doi: 10.1111/j.1532-5415.2008.02013.x. - DOI - PubMed
    1. Bucerius J, Gummert JF, Borger MA, Walther T, Doll N, Falk V, Schmitt DV, Mohr FW. Predictors of delirium after cardiac surgery delirium: effect of beating-heart (off-pump) surgery. J Thorac Cardiovasc Surg. 2004;127:57–64. doi: 10.1016/S0022-5223(03)01281-9. - DOI - PubMed
    1. Martin BJ, Buth KJ, Arora RC, Baskett RJ. Delirium as a predictor of sepsis in post-coronary artery bypass grafting patients: a retrospective cohort study. Crit Care. 2010;14:R171. doi: 10.1186/cc9273. - DOI - PMC - PubMed