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. 2010;65(11):1115-7.
doi: 10.1590/s1807-59322010001100010.

Frequency of the mdr-1 C>T gene polymorphism in patients with COPD

Omer Tamer Dogan  1 , Nurkay Katrancioglu, Ouz Karahan, Gülizar Canan Sanli, Ali Zorlu, Sinasi Manduz
Affiliations

Frequency of the mdr-1 C>T gene polymorphism in patients with COPD

Omer Tamer Dogan et al. Clinics (Sao Paulo). 2010.

Abstract

Background and aim: The multi-drug resistant-1 (MDR-1) gene is located on human chromosome 7 and encodes a glycosylated membrane protein that is a member of the ATP-binding cassette transporters superfamily. The aim of the study was to reveal the role of the C3435T MDR-1 gene polymorphism in chronic obstructive pulmonary disease.

Method: DNA samples from 41 patients with chronic obstructive pulmonary disease and 50 healthy control participants were used to compare MDR-1 gene profiles. Genotyping assays were performed using the StripAssay technique that is based on reverse-hybridization.

Results: The T allele polymorphism in the MDR-1 gene located at position 3435 in exon 26 was shown to correlate with chronic obstructive pulmonary disease.

Conclusion: These preliminary results suggest that the T allele polymorphism of the MDR-1 gene is associated with chronic obstructive pulmonary disease.

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