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. 2011 Feb 18;13(4):706-8.
doi: 10.1021/ol102942w. Epub 2011 Jan 18.

Ruthenium-catalyzed oxidative vinylation of heteroarene carboxylic acids with alkenes via regioselective C-H bond cleavage

Takumi Ueyama  1 , Satoshi Mochida, Tatsuya Fukutani, Koji Hirano, Tetsuya Satoh, Masahiro Miura
Affiliations

Ruthenium-catalyzed oxidative vinylation of heteroarene carboxylic acids with alkenes via regioselective C-H bond cleavage

Takumi Ueyama et al. Org Lett. .

Abstract

The ruthenium-catalyzed oxidative vinylation of thiophene-2-carboxylic acids with alkenes efficiently proceeds through directed C-H bond cleavage to give the corresponding 3-vinylated products. Similarly, benzothiophene-, benzofuran-, pyrrole-, and indolecarboxylic acids also undergo regioselective vinylation.

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