Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Jan-Feb;31(1):29-34.
doi: 10.4103/0256-4947.75775.

OX40/OX40L in systemic lupus erythematosus: association with disease activity and lupus nephritis

Mohamed N Farres  1 , Dina S Al-Zifzaf, Alaa A Aly, Nermine M Abd Raboh
Affiliations

OX40/OX40L in systemic lupus erythematosus: association with disease activity and lupus nephritis

Mohamed N Farres et al. Ann Saudi Med. 2011 Jan-Feb.

Abstract

Background and objectives: OX40-OX40L interaction is implicated in the pathogenesis of systemic lupus erythematosus (SLE). We evaluated the role of OX40/OX40L as markers of disease activity and nephritis in SLE patients.

Design and setting: Case-control study conducted in 2009 on SLE patients attending the outpatient clinics of Ain Shams University Hospital, Egypt.

Patients and methods: We assessed the percentage of CD4+ T-lymphocytes expressing OX40 by flowcytometry, and serum OX40 ligand (OX40L) levels in 40 patients with SLE (20 with lupus nephritis and 20 without) and in 20 healthy controls. Disease activity was assessed by the University of Toronto SLE disease activity index (SLEDAI).

Results: The percentage of CD4+ T-lymphocytes expressing OX40 was significantly higher in SLE patients than in controls, and in patients with lupus nephritis than in those without. OX40 expression correlated positively with both serum creatinine levels and SLEDAI. OX40 expression was the highest in patients with class V lupus nephritis and lowest in class II. Serum OX40L levels were significantly higher in SLE patients than in controls, and in patients with nephritis than in those without. Serum OX40L levels correlated with serum creatinine levels but not with SLEDAI. OX40 expression on CD4+ T-cells had a higher sensitivity and specificity in diagnosing lupus nephritis than both OX40L and anti-double-stranded DNA levels.

Conclusion: OX40-OX40L interaction plays a role in the pathogenesis of SLE. The expression of OX40 on CD4+ T-lymphocytes and the serum level of OX40L may act as markers of lupus nephritis. Measurements of percentages of CD4+ T-lymphocytes expressing OX40 may serve as an indicator of disease activity in SLE.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Correlation between OX40 expression on CD4+ T-cells and serum creatinine levels.
Figure 2
Figure 2
Correlation between OX40 expression on CD4+ T-cells and disease activity.
Figure 3
Figure 3
Correlation between serum levels of OX40L and creatinine.
Figure 4
Figure 4
ROC curves for OX40 expression and serum OX40L, and the presence of nephritis in SLE patients.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Weinberg AD. OX40: Targeted immunotherapy--implications for tempering autoimmunity and enhancing vaccines. Trends Immunol. 2002;23:102–9. - PubMed
    1. Weinberg AD, Evans DE, Thalhofer C, Shi T, Prell RA. The generation of T cell memory: A review describing the molecular and cellular events following OX40 (CD134) engagement. J Leukoc Biol. 2004;75:962–72. - PubMed
    1. Manku H, Graham DS, Vyse TJ. Association of the co-stimulator OX40L with systemic lupus erythematosus. J Mol Med. 2009;87:229–34. - PubMed
    1. Cunninghame Graham DS, Graham RR, Manku H, Wong AK, Whittaker JC, Gaffney PM, et al. Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus. Nat Genet. 2008;40:83–9. - PMC - PubMed
    1. Tucci M, Calvani N, Richards HB, Quatraro C, Silvestris F. The interplay of chemokines and dendritic cells in the pathogenesis of lupus nephritis. Ann N Y Acad Sci. 2005;1051:421–32. - PubMed