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. 2011 Jan 14;17(2):249-53.
doi: 10.3748/wjg.v17.i2.249.

Risk factors for hilar cholangiocarcinoma: a case-control study in China

Wen-Ke Cai  1 , Hui Sima, Ben-Dong Chen, Guang-Shun Yang
Affiliations

Risk factors for hilar cholangiocarcinoma: a case-control study in China

Wen-Ke Cai et al. World J Gastroenterol. .

Abstract

Aim: To study the association between hilar cholangiocarcinoma (HC) and pre-existing medical conditions.

Methods: Three hundred and thirteen HC patients admitted to the Eastern Hepatobiliary Surgery Hospital (Shanghai, China) in 2000-2005 and 608 healthy controls were enrolled in this study. Association between HC and pre-existing medical conditions was studied with their adjusted odds ratio (OR) calculated by logistic regression analysis.

Results: The prevalence of choledocholithiasis (adjusted OR = 2.704, P = 0.039), hepatolithiasis (adjusted OR = 3.278, P = 0.018), cholecystolithiasis (adjusted OR = 4.499, P < 0.0001), cholecystectomy (adjusted OR = 7.012, P = 0.004), biliary ascariasis (adjusted OR = 7.188, P = 0.001), liver fluke (adjusted OR = 10.088, P = 0.042) and liver schistosomiasis (adjusted OR = 9.913, P = 0.001) was higher in HC patients than in healthy controls.

Conclusion: Biliary tract stone disease (choledocholithiasis, hepatolithiasis, cholecystolithiasis) and parasitic liver disease (biliary ascariasis, liver fluke, liver schistosomiasis) are the risk factors for HC in Chinese population.

Keywords: Choledocholithiasis; Hepatitis B virus; Hepatitis C virus; Hilar cholangiocarcinoma; Liver fluke.

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Figures

Figure 1
Figure 1
Distribution of age and sex in patients with hilar cholangiocarcinoma admitted to the Eastern Hepatobiliary Surgery Hospital (Shanghai, China) during 2000-2005.
See this image and copyright information in PMC

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