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. 2011 Apr;118(4):549-53.
doi: 10.1007/s00702-010-0544-y. Epub 2011 Jan 19.

Micrographia induced by pallidal DBS for segmental dystonia: a subtle sign of hypokinesia?

Christian Blahak  1 , Hans-Holger Capelle, Hansjoerg Baezner, Thomas M Kinfe, Michael G Hennerici, Joachim K Krauss
Affiliations

Micrographia induced by pallidal DBS for segmental dystonia: a subtle sign of hypokinesia?

Christian Blahak et al. J Neural Transm (Vienna). 2011 Apr.

Abstract

Recently parkinsonism has been reported as a rare side effect of globus pallidus internus (GPi) deep brain stimulation (DBS) for dystonia. In the present systematic prospective study in 11 patients with segmental dystonia not affecting distal arm function, we could demonstrate significant changes in handwriting characterized by mild micrographia following GPi-DBS. We propose that this finding reflects GPi-DBS-induced disturbances of basal ganglia function in terms of a mild hypokinetic syndrome, as a result of outflow alterations in pallido-thalamo-cortical pathways.

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