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. 1990 Dec;87(24):9923-7.
doi: 10.1073/pnas.87.24.9923.

Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster

J C Eissenberg  1 , T C James, D M Foster-Hartnett, T Hartnett, V Ngan, S C Elgin
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Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster

J C Eissenberg et al. Proc Natl Acad Sci U S A. 1990 Dec.

Abstract

We report here that a point mutation in the gene which encodes the heterochromatin-specific nonhistone chromosomal protein HP-1 in Drosophila melanogaster is associated with dominant suppression of position-effect variegation. The mutation, a G-to-A transition at the first nucleotide of the last intron, causes missplicing of the HP-1 mRNA. This suggests that heterochromatin-specific proteins play a central role in the gene suppression associated with heterochromatic position effects.

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