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Review
. 2011 Jan 20;30(1):11.
doi: 10.1186/1756-9966-30-11.

The association of Streptococcus bovis/gallolyticus with colorectal tumors: the nature and the underlying mechanisms of its etiological role

Ahmed S Abdulamir  1 , Rand R Hafidh, Fatimah Abu Bakar
Affiliations
Review

The association of Streptococcus bovis/gallolyticus with colorectal tumors: the nature and the underlying mechanisms of its etiological role

Ahmed S Abdulamir et al. J Exp Clin Cancer Res. .

Abstract

Streptococcus bovis (S. bovis) bacteria are associated with colorectal cancer and adenoma. S. bovis is currently named S. gallolyticus. 25 to 80% of patients with S. bovis/gallolyticus bacteremia have concomitant colorectal tumors. Colonic neoplasia may arise years after the presentation of bacteremia or infectious endocarditis of S. bovis/gallolyticus. The presence of S. bovis/gallolyticus bacteremia and/or endocarditis is also related to the presence of villous or tubular-villous adenomas in the large intestine. In addition, serological relationship of S. gallolyticus with colorectal tumors and direct colonization of S. gallolyticus in tissues of colorectal tumors were found. However, this association is still under controversy and has long been underestimated. Moreover, the etiological versus non-etiological nature of this associationis not settled yet. Therefore, by covering the most of up to date studies, this review attempts to clarify the nature and the core of S. bovis/gallolyicus association with colorectal tumors and analyze the possible underlying mechanisms.

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Figures

Figure 1
Figure 1
Illustration for the discovered and suggested mechanisms underlying the etiological association of S. bovis/gallolyticus (SBG) bacteria with promoting, propagating, or initiating colorectal tumors, bacteremia, and endocarditis.
See this image and copyright information in PMC

References

    1. Wilson WR, Thompson RL, Wilkowske CJ, Washington JA, Giuliani ER, Geraci JE. JAMA. 2. Vol. 245. 1981. Short-term therapy for streptococcal infective endocarditis. Combined intramuscular administration of penicillin and streptomycin; pp. 360–363. - DOI - PubMed
    1. Reynolds JG, Silva E, McCormack WM. Association of Streptococcus bovis bacteremia with bowel disease. J Clin Microbiol. 1983;17:696–697. - PMC - PubMed
    1. Leport C, Bure A, Leport J, Vilde JL. Incidence of colonic lesions in Streptococcus bovis and enterococcal endocarditis. Lancet. 1987;1:748. doi: 10.1016/S0140-6736(87)90391-6. - DOI - PubMed
    1. Zarkin BA, Lillemoe KD, Cameron JL, Effron PN, Magnuson TH, Pitt HA. The triad of Streptococcus bovis bacteremia, colonic pathology, and liver disease. Ann Surg. 1990;211:786–791. doi: 10.1097/00000658-199006000-00019. discussion 791-782. - DOI - PMC - PubMed
    1. Kok H, Jureen R, Soon CY, Tey BH. Colon cancer presenting as Streptococcus gallolyticus infective endocarditis. Singapore Med J. 2007;48:e43–45. - PubMed

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