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Comment
. 2011 Jan 17;15(1):105.
doi: 10.1186/cc9375.

Treatment with recombinant human activated protein C: one size does not fit all

Marcel Levi  1
Affiliations
Comment

Treatment with recombinant human activated protein C: one size does not fit all

Marcel Levi. Crit Care. .

Abstract

Protein C plays an important role in the coagulopathy associated with sepsis and probably also in the pathogenesis of sepsis-induced organ dysfunction. Plasma levels of protein C strongly correlate with clinical outcome in patients with severe sepsis. The RESPOND (Research Evaluating Serial Protein C Levels in Severe Sepsis Patients on Drotrecogin Alfa [Activated]) study shows that administration of recombinant human activated protein C in patients with severe sepsis with alternative dose regimens adjusted to plasma levels of protein C results in higher plasma levels of protein C. This may potentially translate to a better clinical outcome in patients with severe sepsis, although that was not directly shown in this trial.

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References

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