Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Jun;56(6):588-91.
doi: 10.1016/j.archoralbio.2010.12.002. Epub 2011 Jan 17.

Presence of wax esters and squalene in human saliva

Andrew J Brasser  1 , Christopher A Barwacz, Deborah V Dawson, Kim A Brogden, David R Drake, Philip W Wertz
Affiliations

Presence of wax esters and squalene in human saliva

Andrew J Brasser et al. Arch Oral Biol. 2011 Jun.

Abstract

Objective: The purpose of this study was to determine the presence and relative composition of neutral lipids in human saliva.

Design: Whole unstimulated saliva was collected from 12 subjects ranging from 21 to 29 years old. Samples were lyophilized, and lipids were extracted using chloroform-methanol. Lipids were analysed by thin-layer chromatography.

Results: Human saliva contains cholesterol, fatty acids, triglycerides, wax esters, cholesterol esters and squalene. The mean total neutral lipid content was 12.1±6.3 μg/ml.

Conclusions: These lipids in human saliva closely resemble the lipids found on the skin surface. These salivary lipids are most likely produced by the sebaceous follicles in the oral mucosa and sebaceous glands associated with major salivary glands.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Carbon density profile of charred lipids after separation by TLC. CH, cholesterol; FA, fatty acids; TG, triglyserides; WE, wax esters; CE, cholesterol esters; SQ, squalene
Figure 2
Figure 2
Gas chromatography of squalene isolated from human saliva. (a) mixture of authentic squalene and isolated material (b) authentic squalene (c) squalene isolated from saliva. In each case the retention time of the single peak was 19.1 min.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Slomiany BL, Murty VL, Slomiany A. Salivary lipids in health and disease. Progress in Lipid Research. 1985;24(4):311–324. - PubMed
    1. Larsson B, Olivecrona G, Ericson T. Lipids in human saliva. Archives of oral Biology. 1996;41(1):105–110. - PubMed
    1. Meleti M, Vescovi P, Mooi WJ, van der Waal I. Pigmented lesions of the oral mucosa and perioral tissues: a flow-chart for the diagnosis and some recommendations for the management. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics. 2008;105(5):606–616. - PubMed
    1. Gulec AT, Haberal M. Lip and oral mucosal lesions in 100 renal transplant recipients. Journal of the American Acadamy of Dermatology. 2010;62(1):96–101. - PubMed
    1. Gorsky M, Buchner A, Fundoianu-Dayan D, Cohen C. Fordyce’s granules in the oral mucosa of adult Israeli Jews. Community Dentistry and Oral Epidemiology. 1986;14(4):231–232. - PubMed

Publication types